CID-NUNEZ, JOSE MARIA,荷西 玛利亚 席 诺内姿,荷西 瑪利亞 席 諾內姿,TRABANCO-SUAREZ, ANDRES AVELINO,安德烈 雅华利诺 卓班克 苏瑞兹,安德烈 雅華利諾 卓班克 蘇瑞茲,MACDONALD, GREGOR JAMES,格雷果 詹姆士 麦克当纳,格雷果 詹姆士 麥克當納,DUVEY, GUILLAUME ALBERT JACQUES,居礼安
申请号：
TW097135273
公开号：
TWI445532B
申请日:
2008.09.12
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I)wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors-subtype 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.本發明係關於一種新穎化合物,尤其新穎的式(I)之吡啶酮衍生物:其中所有基團係如本申請案及申請專利範圍中所定義。本發明化合物為代謝型受體-亞型2("mGluR2")之正向異位調節劑,其適用於治療或預防與麩胺酸鹽功能障礙有關之神經及精神病症及涉及代謝型受體之mGluR2亞型之疾病。詳言之,該等疾病為選自焦慮、精神分裂症、偏頭痛、抑鬱及癲癇症之群的中樞神經系統病症。本發明亦係關於醫藥組合物及製備該等化合物及組合物之方法,以及該等化合物用於預防及治療該等涉及mGluR2之疾病的用途。
