Method for inhibiting the formation of SET1 family core complexes

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专利权人:

Michael S. Cosgrove

发明人:

Michael S. Cosgrove,Anamika Patel

申请号：

US13415474

公开号：

US08715678B2

申请日:

2012.03.08

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Disclosed in this specification is a method for inhibiting the formation of vertebrate SET1 family core complexes. A guanidinium-containing molecule is used to competitively inhibit the binding of the N-SET region of a SET1 protein to WDR5, thus inhibiting the formation of the SET1 family core complex. The guanidinium-containing molecule may be, for example, an arginine-containing peptide.

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