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VIRAL VECTORS WITH MODIFIED TRANSDUCTION PROFILES AND METHODS OF MAKING AND USING THE SAME
专利权人:
发明人:
申请号:
EP12744695.3
公开号:
EP2673289A1
申请日:
2012.02.10
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention provides AAV capsid proteins, virus capsids comprising said capsid proteins and virus vectors comprising said capsid proteins, wherein the AAV capsid proteins have one or more mutations, wherein the mutation(s) result in a phenotype of decreased liver transduction and/or reduced glycan binding affinity as compared to a control. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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