PROCESS FOR PREPARING THE ANTI-TUMOR AGENT 6-(7-((1-AMINOCYCLOPROPYL) METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND ITS CRYSTALLINE

• 收藏
• 分享

专利权人:

ADVENCHEN PHARMACEUTICALS LLC

发明人:

CHEN, GUOQING, PAUL

申请号：

EP14740190

公开号：

EP2945931A4

申请日:

2014.01.17

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention relates a new process to synthesize 6-(7-((1-aminocyclo-propyl)-methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide (AL3810) by deprotection of substituted benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)-methyl)cyc-lopropylcarbamate (Formula I) under a diluted or weak acidic condition. A stable crystalline form of 6-(7-((1-aminocyclo-propyl)-methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide has also been prepared.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/