An endoscopic reposable surgical clip applier is provided and includes ahandleassembly and an endoscopic assembly. The endoscopic assembly is selectivelyconnectableto and in mechanical communication with the handle assembly and includes ashaft assembly.The shaft assembly includes a pair of jaws pivotably and fixedly supported in,and extendingfrom a distal portion of the shaft assembly, a spindle assembly supportedwithin theendoscopic assembly, and a lockout mechanism fixedly supported on the pair ofjaws. Adistal end of the spindle is operatively engaged with the pair of jaws toeffectuate an openingand a closing of the pair of jaws upon an axial translation of the spindle.The lockoutmechanism is in selective engagement with the spindle and includes a firstposition thatenables distal advancement of the spindle and a second position that inhibitsdistaladvancement of the spindle.