CHOU, MIN YUAN,周民元,CHIU, WEI CHUN,邱伟钧,邱偉鈞,LAI, YA PING,赖雅萍,賴雅萍
申请号：
TW100148544
公开号：
TW201325612A
申请日:
2011.12.26
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention relates to novel Fc fusion proteins comprising a novel collagenous motif which stabilizes the trimeric structure of the fusion partners. Oligomerization of soluble binding domains improves target binding strength and potentially increases therapeutic effects with reduced dosing regimen. Also disclosed are pharmaceutical compositions comprising the members of the TNF receptor family, their use in the treatment of acute and chronic immunological diseases such as rheumatoid arthritis.本發明關於新穎的Fc融合蛋白，包含穩定融合蛋白的三倍體結構之新穎膠原蛋白模體。可溶性結合區域的寡聚合作用可作為改善標靶結合強度及有效地增加療效，與降低劑量療程。本案亦揭露包含TNF受體家族的成員之醫藥組成物及其應用於急性及慢性免疫疾病的用途，例如風濕性關節炎。
