The present invention relates to a stable pharmaceutical composition comprising a therapeutically effective quantity of a NSAID having a pulsatile release profile, such as Diclofenac or a pharmaceutically acceptable salt, prodrug, or derivative thereof, and a therapeutically effective quantity of a PPI, such as Esomeprazole or a pharmaceutically acceptable salt, prodrug, or derivative thereof, in a multi-unit dosage combination, and a process for the preparation thereof.