PURPOSE: A composition for skin whitening is provided to suppress protease activated receptor (PAR)-2 in keratinocytes and the delivery of melanosome generated in melanocytes into keratinocytes, thereby suppressing or reducing pigmentation with excellent skin whitening effects.CONSTITUTION: A pharmaceutical composition for preventing pigmentary disorders caused by excessive accumulation of melanin contains lobaric acid as an active ingredient. A food composition for treating or preventing pigmentary disorders or improving skin whitening contains lobaric acid as an active ingredient. A cosmetic composition for preventing or treating pigmentary disorders and improving skin whitening contains lobaric acid as an active ingredient. Lobaric acid suppresses the delivery of melanosome and reduces pigmentation by suppressing the activation of PAR-2 in keratinocytes.COPYRIGHT KIPO 2013본 발명은 로바릭산을 유효성분으로 포함하는 피부 미백용 조성물을 제공한다. 본 발명의 유효성분인 로바릭산은 케라티노사이트의 PAR-2을 저해하고, 멜라노사이트에서 생성된 멜라노좀의 케라티노사이트로의 전달을 억제하여, 피부의 색소 침착을 감소시키고, 우수한 피부 미백 효과를 나타내며, 멜라닌의 과다 축적으로 인한 피부 색소성 질환의 개선, 예방 또는 치료효과를 나타낸다.
