GEHLSEN, KURT R.,JONES, TIMOTHY DAVID,CARR, FRANCIS JOSEPH,HEARN, ARRON
申请号：
PL14775634
公开号：
PL2971038T3
申请日:
2014.03.03
申请国别(地区):
PL
年份:
2020
代理人:
摘要：
The present application relates to modified T cell epitopes derived from fungal ribotoxins, including a-sarcin, clavin, gigantin, mitogillin, and restrictocin, as well as modified ribotoxin molecules comprising one or more of the modified epitopes. The modified ribotoxin molecules inhibit protein synthesis, like the wild type ribotoxins, but exhibit reduced immunogenicity as compared to the corresponding wild type ribotoxin. Another aspect relates to a fusion protein which comprises a modified ribotoxin fused or conjugated or otherwise linked to a targeting molecule that is effective for binding a target of interest. Another aspect relates to the use of the modified ribotoxin or fusion protein for treating or managing a disease or condition.
