WEBSTER, GORDON D.,MCKENZIE, SUZANNE P.,LO, KIN-MING,STEIN, PASCAL ANDRE
申请号：
AT06846989
公开号：
AT555125T
申请日:
2006.12.20
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.
