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Pleuromutilin derivatives for the treatment of diseases mediated by microbes
专利权人:
Nabriva Therapeutics AG
发明人:
Mang, Rosemarie,Heilmayer, Werner,Bulusu, Atchyuta Rama Chandra Murty,Ferencic, Mathias,Strickmann, Dirk,Novak, Rodger,Badegruber, Rudolf
申请号:
AU2008229609
公开号:
AU2008229609B2
申请日:
2008.03.19
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphuratom and R are in vicinal position (if m = 0 then R is in position2', and if m = 1 then R is on position 1'); R is ethyl or vinyl;R is hydrogen or (C)alkyl; R is hydrogenor - (C)cycloalkyl, or - unsubstituted (C)alkyl,or - (C)alkyl substituted by one or more of - hydroxy; preferablyone or two, - methoxy, - halogen, - (C)cycloalkyl, or RandR together with the nitrogen atom to which they are attached form a5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogenand 1 additional heteroatome e. g. selected from N or O, or R is hydroxyand R is formyl; R is OH, OR, a halogen atom,or - with the proviso that R is bound to 2' R represents-O-(CH)-O- with p is 2 or 3; R is unsubstituted(C)alkyl or (C)cycloalkyl.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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