A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material, the thrombectomy wire (30) comprising a core (32) having a proximal region (34) and a distal region (37) and being rotatable by a motor (14). The distal region has a smaller diameter than the proximal region. A cable (90) is coupled to the distal region of the core and extends distally thereof. A torque tube (97) is positioned over the cable and a coil (91) positioned over a distal portion (96) of the cable. The distal portion of the cable has a non-linear configuration. A first covering material (99) positioned over the coil.