Desmond John Best,Sing Yeung Mak,Barry Sidney Orlek,Geracimos Rassias,Pamela Joan Theobald
申请号：
US12676158
公开号：
US08288389B2
申请日:
2008.09.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazineor a pharmaceutically acceptable salt thereof, in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt to processes for the preparation of the compound or its salt to compositions containing it and to its use in the treatment or prophylaxis of neurological or psychiatric diseases, such as cognitive impairment, fatigue or a sleep disorder, for example in a mammal such as a human.The compound or a salt thereof has affinity for and is an antagonist and/or inverse agonist of the histamine H3 receptor.
