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Biodegradable nano, meso and micropolymer particles to keep lung surface tension low and protect lung surfactant
专利权人:
ユストゥス-リービッヒ-ウニヴェルジテート・ギーセン;ユストゥス-リービッヒ-ウニヴェルジテート・ギーセン
发明人:
ベック-ブロイクシッター モーリッツ,シュメール トーマス,ゲッスラー トビアス,ベック-ブロイクシッター モーリッツ
申请号:
JP2013519960
公开号:
JP2013545717A
申请日:
2011.07.18
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
Biocompatible nano-, meso- or micro polymer particle for binding pathogenic proteins, which penetrate into the lining layer of the lung, is claimed. The particle exhibits: a diameter of 20 nm-10 mu m, and is water insoluble; a positive surface charge; a low surface hydrophobicity, which is equivalent to a contact angle of less than 120[deg] ; an isoelectric point greater than 5, such that the particle is present as positively charged particle under physiological conditions in the lungs, and greater than the isoelectric point of the pathogenic protein to be bonded; and a positive zeta-potential. Biocompatible nano-, meso- or micro polymer particle for binding pathogenic proteins, which penetrate into the lining layer of the lung, is claimed. The particle exhibits: a diameter of 20 nm-10 mu m, and is water insoluble; a positive surface charge; a low surface hydrophobicity, which is equivalent to a contact angle of less than 120[deg] , measured according to the sessile drop method; an isoelectric point greater than 5, such that the particle is present as positively charged particle under physiological conditions in the lungs, and greater than the isoelectric point of the pathogenic protein to be bonded; and a positive zeta-potential greater than 20 mV. An independent claim is also included for preparing the polymer particle, comprising dissolving the polymer in a first, polar aprotic solvent, precipitating particle in the polymer solution placed in a second solvent or by dialyzing, where the first and second solvents are completely or partially miscible with one another, but the polymer is not soluble in the second solvent, and removing the organic solvent and obtaining the particle in a suspension. ACTIVITY : Respiratory-Gen; Antiinflammatory; Hypotensive; Antiasthmatic; Hemostatic; CNS-Gen; Dermatological; Antimicrobial; Antiemetic; Cytostatic. No biological data given. MECHANISM OF ACTION : None given.本発明は、肺の粘膜層に浸透する病原体タンパク質と結合することのできる生体適合性ナノ、メソ及びマイクロポリマー粒子に関する。肺粘膜層
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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