A medical agent dispensing system and surgical instruments that employ the medical agent dispensing system are provided. The dispensing system may be structured for use with a surgical severing/stapling instrument structured for severing and stapling tissue. The dispensing system may include at least one storage reservoir structured for storing at least a component of a medical agent and a pump in communication with the storage reservoir a delivery tube in communication with the pump which is structured to receive a quantity of the medical agent from the storage reservoir during operation of the pump and, at least one agent tube in communication with the delivery tube which is structured for communication with a least one agent port formed in a staple cartridge or an anvil of the surgical instrument for dispensing the medical agent therethrough.
