#$%^&*AU2005202062B220120816.pdf#####ABSTRACT The invention relates to uses of GAG-peptide complexes and polypeptides obtained from connective tissue albeit indirectly which are substantially free of DNA for the treatment, protection and restoration of skin and connective tissues. The invention provides a topical composition comprising at least one GAG-peptide complex comprising two or three GAG-chains.14/19 0 0. am E 0 m C .00 low CL Lml + CL 0 G Cf m La CL 0 oL 00 1 Am. 0 10 0D E W: 0 00 00 0r 0 4) a)E