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STABILISANT POUR UNE PRÉPARATION DE PROTÉINE CONTENANT DE LA MÉGLUMINE ET SON UTILISATION
专利权人:
CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人:
申请号:
EP06766537.2
公开号:
EP1908482B1
申请日:
2006.06.09
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
An objective of the present invention is to provide methods for stabilizing proteins and methods for suppressing protein aggregation, which comprise the step of adding meglumine to the proteins. Another objective of the present invention is to provide agents for suppressing protein aggregation, which comprise meglumine. Still another objective of the present invention is to provide pharmaceutical compositions comprising antibody molecules stabilized by meglumine, methods for producing the pharmaceutical compositions, and kits comprising the pharmaceutical compositions. To achieve the objectives described above, the present inventors assessed the antibody-stabilizing effect of meglumine, an amino sugar. As a result, the inventors discovered that meglumine was useful as a stabilizer for antibody molecules and also as an excipient for freeze-dried preparations.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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