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Functionalized drugs and polymers derived therefrom
专利权人:
Rao S. Bezwada
发明人:
Rao S. Bezwada
申请号:
US12706735
公开号:
US08409559B2
申请日:
2010.02.17
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Compounds selected from:where DRUG-OH, DRUG-COOH and DRUG-NH2 are biologically active compounds each X is independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone moiety), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO—, where y is 2-4 or 6-24 and —(CH2CH2O)zCH2COO—, where z is 2-24 each Y is independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester moiety), —COCH2CH2CH2CH2CH2O— (caprolactone ester moiety), —CO(CH2)mO—, where m is 2-4 or 6-24 and —COCH2O(CH2CH2O)n— where n is between 2-24 R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched and p is 1-6. Multi-functional compounds and drug dimers, oligomers and polymers are also disclosed.
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