Daniel Galtier;Jean-Michel Altenburger;Frederic Petit;Valerie Fossey
发明人:
Jean-Michel Altenburger,Valerie Fossey,Daniel Galtier,Frederic Petit
申请号:
US13894872
公开号:
US08653276B2
申请日:
2013.05.15
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention is directed to compounds of the general formula:as defined herein, and pharmaceutical compositions thereof. The invention is also directed to their therapeutic use as urotensin II receptor antagonists, e.g., in the treatment of cardiac, coronary, and central nervous system disorders. In particular embodiments, the invention relates to 5,6-bisaryl-2-pyridinecarboxamides, to their preparation and to their therapeutic use as urotensin II receptor antagonists.