Disclosing therapeutic conjugate includes the compound functional r NA of small-molecule drug. In addition,It include carrier polypeptide disclosed herein is the composition comprising nano particle, the compound small-molecule drug with functional RNA molecule, wherein carrier polypeptide includes cell targeted section, cell-penetrating section, with an oligonucleoti unsticking section, and this nanoparticle of manufacture and use. A kind for the treatment of of method is further described with cancer, including giving a kind of composition of a effective amount of nano particle of the subject, nanoparticle includes carrier polypeptide, the small molecule chemotherapeutic drug compound with functional RNA molecule, the carrier polypeptide includes cell-targeting part, cell-penetrating section and a kind of segment of oligonucleotide binding. Pharmaceutical composition, product and kit are also described, includes the nanoparticle.
