YANG, KUO HUA,杨国华,楊國華,YANG, CHIH SHENG,杨至圣,楊至聖,LIN, HSUEN YAU,林煊曜,林煊曜
申请号：
TW100101169
公开号：
TWI433904B
申请日:
2011.01.12
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
Disclosed is a donepezil transdermal patch comprising a backing layer and a pressure sensitive adhesive matrix layer, wherein the pressure sensitive adhesive matrix layer comprises donepezil free base and an acrylic pressure sensitive adhesive agent selected from the group consisting of a copolymer of 2-ethylhexyl acrylate and vinyl acetate and a copolymer of 2-ethylhexyl acrylate, vinyl acetate, and hydroxyl-containing monomers, and wherein on the basis of the total weight of the copolymer, an amount of 2-ethylhexyl acrylate is about 65 to 75 wt%, an amount of vinyl acetate is about 25 to 35 wt%, and an amount of hydroxyl-containing monomers is about 0 to 10 wt%.本發明揭示一種多奈哌齊經皮貼片,其包含支持層及壓敏黏合劑基質層,其中壓敏黏合劑基質層包含多奈哌齊游離鹼及選自由2-乙基己基丙烯酸酯與乙酸乙烯酯之共聚物及2-乙基己基丙烯酸酯、乙酸乙烯酯與含羥基單體之共聚物所組成之群之丙烯酸系壓敏黏合劑,且其中以共聚物之總重量計,2-乙基己基丙烯酸酯之含量為約65至75重量%,乙酸乙烯酯之含量為約25至35重量%,及含羥基單體之含量為約0至10重量%。(無元件符號說明)
