Provided are: a method for producing an aqueous ophthalmic composition, the method including the wet grinding of a mixture containing a carbonic anhydrase inhibitor, a cellulose derivative, and water, wherein the viscosity of a 2 mass% aqueous solution of the cellulose derivative at 20 DEG C is 60 mPa.s or less and an aqueous ophthalmic composition containing a carbonic anhydrase inhibitor, a cellulose derivative, and water, wherein the absorbance of the aqueous ophthalmic composition with an optical path length of 1 mm at a wavelength of 600 nm is 1.1 or less, and the viscosity of a 2 mass% aqueous solution of the cellulose derivative at 20 DEG C is 60 mPa.s or less.一種眼科用水性組成物的製造方法、以及一種眼科用水性組成物。該眼科用水性組成物的製造方法係包含將含有碳酸酐酶抑制劑、纖維素衍生物及水的混合物進行濕式粉碎處理,且纖維素衍生物的2質量%水溶液之在20℃中的黏度為60mPa.s以下。該眼科用水性組成物係含有碳酸酐酶抑制劑、纖維素衍生物及水,而眼科用水性組成物之在波長600nm的光路長1mm之吸光度為1.1以下,且纖維素衍生物的2質量%水溶液之在20℃的黏度為60mPa.s以下。
