PROBLEM TO BE SOLVED: To provide a therapeutic or a prophylactic agent which shows good pharmacokinetics in diseases, including depression, anxiety disorder, schizophrenia, Alzheimers disease, Parkinsons disease, Huntington chorea, eating disorders, hypertension, digestive diseases, drug dependency, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-mediated diseases and alopecia.SOLUTION: There are provided quinoline derivatives of formula (1) having an arginine-vasopressin 1b receptor antagonistic action and their pharmaceutically acceptable salts.COPYRIGHT: (C)2013,JPO&INPIT【課題】うつ病、不安障害、統合失調症、アルツハイマー病、パーキンソン病、ハンチントン舞踏病、摂食障害、高血圧、消化器疾患、薬物依存症、てんかん、脳梗塞、脳虚血、脳浮腫、頭部外傷、炎症、免疫関連疾患、脱毛症等の疾患において良好な体内動態を示す治療又は予防剤を提供すること。【解決手段】アルギニン-バソプレッシン1b受容体拮抗作用を有する、一般式(1)で表されるキノリン誘導体、又はその医薬上許容される塩。【選択図】なし
