(57)< Abstract > This invention it possesses general expression (1) offers the salt which on chemical compound and its medicine which is permitted. In formula, R1 and R2 to be the same to independence, or to differ, hydrogen, the alkyl group, the arukeniru basis and the benzyl basis, the alkynyl group and the alkoxyl basis, the aryloxy group and the acyloxy basis, the carbonyloxy group and the carbamoyloxy basis, halogen, the hydroxyl basis and the nitro group, the cyano group, the azide basis, the formyl basis, the hydrazino basis and the acyl basis, the amino group, - (in formula, as for R c hydrogen and the acyl basis, it is the alkyl group or the aryl basis,) to be SR c, or as for R1 and R2 becoming simultaneous, formula - O (CH2) nO- (in formulaN integer displays 1 or 2) to form the basis, R3 H, F and the halogen atom, the nitro group, the amino group, to be the hydroxyl basis, or the cyano group, or, R2 and R3 becoming simultaneous and formula - to form the basis of O (CH2) nO- (in formula, n integer 1 or 2 is displayed,), R4 H, F and C1-3 alkyl group, C2-3 arukeniru basis, to be C2-3 alkynyl group, or C1-3 alkoxyl basis, as for R5 C1-10 alkyl groups, or the propargyl basisSo it is, at the same time R6, as for R7 and R8 in independence C1-10 alkyl group, C2-10 arukeniru basis, C2-10 alkynyl group, the aryl basis or - (CH2) (in formula, as for N it is integer inside range 1, - 10 at the same time as for R9 the hydroxyl basis, alkoxy group, the amino group and the alkyl amino group, jiarukiruamino and the halogen atom, it is the cyano group or nitro group,) it is the NR9 basis.本発明は一般式(1)を有する化合物及びその医薬上許される塩を提供する。式中、R1及びR2は独立に同じであり、又は異なり、水素、アルキル基、アルケニル基、ベンジル基、アルキニル基、アルコキシル基、アリールオキシ基、アシルオキシ基、カルボニルオキシ基、カルバモイルオキシ基、ハロゲン、ヒドロキシル基、ニトロ基、シアノ基、アジド基、ホルミル基、ヒドラジノ基、アシル基、アミノ基、-SRc(式中、Rcは水素、アシル基、アルキル基、又はアリール基である)であり、又はR1及びR2は一緒になって式-O(CH2)nO-(式中、nは整数1又は2を表す)の基を形成し、R3はH、F、ハロゲン原子、ニトロ基、アミノ基、ヒドロキシル基、又はシアノ基であり、又はR2及びR3は一緒になって式-O(CH2)nO-(式中、nは整数1又は2を表す)の基を形成し、R4はH、F、C1-3アルキル基、C2-3アルケニル
