A system and method provides for calculating brain volume in a patient. The method and system includes receiving current intracranial volume data of a patient after a brain injury event and electronically calculating a current brain volume of the patient based on the current brain volume data. The method and system therein electronically calculates a prior brain volume based at least on the current brain volume data and prior age of the patient, the prior brain volume and age being at an earlier point in time, such as prior to a brain injury. The method and system further determines a brain volume change value based on a comparison of the current brain volume and the prior brain volume.