In aspect, a multi-directional endodontic file in the present invention may include a non-cutting portion, a shaft and a plurality of thin cutting blades branching from the shaft toward different directions. More specifically, the cutting blades are branched from an upper portion, a center portion and a lower portion of the shaft. Comparing with conventional endodontic files having a relatively rigid cutting portion, the endodontic file in the present invention has a hollow structure with a plurality of thin cutting blades extending from the shaft, which conducts the cutting in the root canal more conservatively, and since each cutting blade extends toward different directions, each blade operates independently at different levels.