An antibody that specifically recognizes human SIGLEC15 wherein the heavy chain sequence contains a variable region having CDRH1 (DYFMN), CDRH2(QIRNKIYTYATFYA), and CDRH3 (SLEGGDYFDY) and wherein the light chain sequence contains a variable region having CDRL1(RASQSVTISGYSFIH), CDRL2(RASNLAS), and CDRL3(QQSRKSPWT).