NATIONAL CHIAO TUNG UNIVERSITY;Yufeng Jane TSENG;NATIONAL HEALTH RESEARCH INSTITUTES;NATIONAL TAIWAN UNIVERSITY
发明人:
Yufeng Jane TSENG,Yu-Li LIU,Chung-Ming SUN,Hai-Gwo HWU,Chih-Min LIU,Wen-Sung LAI
申请号：
US15125716
公开号：
US20170037448A1
申请日:
2015.04.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. Finding new indications for such drugs will benefit patients who are in needs for a potential new therapy sooner since known drugs are usually with acceptable safety and pharmacokinetic profiles. In this study, repurposing marketed drugs for DAAO inhibitor as new schizophrenia therapy was performed with virtual screening on marketed drugs and its metabolites. The identified and available drugs and compounds were further confirmed with in vitro DAAO enzymatic inhibitory assay.
