SAMJIN PHARMACEUTICAL CO., LTD.;APTABIO THERAPUETICS INC.
发明人:
MOON, Sung Hwan,LEE, Soo Jin,JI, Yu Mi,SHIN, Hee Jong,KI, Min Hyo,PARK, Yong Bin,UM, Ji Hyun
申请号：
PH12019502290
公开号：
PH12019502290A1
申请日:
2019.10.03
申请国别(地区):
PH
年份:
2020
代理人:
摘要：
Disclosed is an oligonucleotide-modified nucleic acid containing at least one 1-á-D-arabinofuranosylcytosine as a modified nucleic acid having therapeutic efficacies and guanosine. More particularly, a novel oligonucleotide-modified nucleic acid containing at least one modified nucleic acid (N) having therapeutic efficacies and being rich in guanosine (G) is synthesized and the fact that the novel oligonucleotide-modified nucleic acid has excellent apoptotic activities on blood cancer cells and drug-resistant blood cancer cells is identified. Based on this, provided is a composition for preventing, ameliorating or treating blood cancer, containing the novel oligonucleotide-modified nucleic acid, and the novel oligonucleotide-modified nucleic acid or a pharmaceutically acceptable salt thereof as an active ingredient.
