BMP A BMP signaling pathway inhibiting peptide derived from a neural stem cell extract and a hair growth promoting or hair loss preventing composition comprising the peptide as an active ingredient
박한규,권한진,설기천,김정옥,황인식,PARK HAN KYU,KWON HAN JIN,SEOL KI CHEON,KIM JEONG OK,HWANG INSIK
申请号：
KR1020190078069
公开号：
KR1020691840000B1
申请日:
2019.06.28
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a hair growth promoting or hair loss preventing composition, and includes peptides represented by SEQ ID NOs: 1 to 3 derived from TGFβ2 released from dermal papilla cells. According to the present invention as described above, by providing a composition and cosmetic composition comprising the TGFβ2- derived peptide and the TGFβ2- derived peptide as an active ingredient, inhibits the BMP signaling pathway that inhibits hair growth and differentiation of hair follicle stem cells It promotes hair growth (anagen) again, thereby promoting hair growth or preventing hair loss.본 발명은 발모촉진 또는 탈모방지 조성물에 관한 것으로서, 모유두세포에서 방출되는 TGFβ2에서 유래한 서열번호 1 내지 3으로 표현되는 펩타이드를 포함한다.상기와 같은 본 발명에 따르면, TGFβ2-유래 펩타이드 및 상기 TGFβ2-유래 펩타이드를 유효성분으로 포함하는 조성물 및 화장료 조성물을 제공함으로써, 모발성장을 저해하는 BMP 신호전달경로를 억제하고 모낭줄기세포의 분화를 촉진시켜 다시 성장기(anagen)를 유도함으로써 발모촉진 또는 탈모방지를 하는 효과가 있다.
