Devices, systems, and methods for removing contrast from luminal organs. In at least one embodiment of a device for removing contrast from luminal organs of the present disclosure, the device comprises an elongated body having at least one lumen extending therethrough and an aperture defined along the elongated body, said aperture configured to facilitate withdrawal of contrast from a mammalian luminal organ, a first detector for detecting a contrast present within the mammalian luminal organ, the detector positioned at or near a distal end of the elongated body, an inflatable balloon coupled to the elongated body proximal to the detector, and a second detector for detecting balloon inflation, the second detector positioned along the elongated body within the balloon.