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NOUVEAUX ANALOGUES DE LA PIPERAZINE EN TANT QU'ANTIVIRAUX ANTIGRIPPAUX A LARGE SPECTRE
专利权人:
BRISTOL MYERS SQUIBB COMPANY
发明人:
CIANCI, CHRISTOPHER W.,GERRITZ, SAMUEL,LI, GUO,PEARCE, BRADLEY C.,PENDRI, ANNAPURNA,SHI, SHUHAO,ZHAI, WEIXU,ZHU, SHIRONG
申请号:
CA2809624
公开号:
CA2809624A1
申请日:
2011.09.06
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
A compound of Formula (I) is set forth, including pharmaceutically acceptable salts thereof, wherein Het is a 5 or 6-membered heterocycle with -N, -O, or -S adjacent to the -Ar substituent or adjacent to the point of attachment for the -Ar substituent; Ar is aryl or heteroaryl; R is -CH3, -CH2F, or -CH=CH2; W is -NO2, -Cl, -Br, -CHO, -CH=CH2, or -CN; X is -Cl, -CH3, or -CN; Y is -CH or -N; and Z is C1-C6 alkyl, C3-C6 cycloalkyl, substituted aryl, substituted heteroaryl, OR1, or NHR1, wherein R1 is selected from the group of H, aryl, heteroaryl, C1-C6 alkyl and C3-C6 cycloalkyl. This compound is useful in compositions for the prevention and treatment of influenza virus.
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