Described herein are materials and methods for reducing the risk of infection at a surgical site performed to restore or repair bone in an animal. Bone graft materials for implantation into a mammal are contemplated containing an antimicrobial agent. In one embodiment the bone graft material comprises both calcium phosphate and povidone-iodine as the antimicrobial agent. In another embodiment the bone graft material further comprises collagen. The bone graft materials are designed so as to maintain the structural integrity and/or handling characteristics of the material upon implantation into a bony site. Various methods for manufacturing the bone graft materials described herein are also contemplated.
