КЛИВЛЕНД Шон Мэттью (GB),ПОЛИК Марк Эндрю (US),САЛОМОН Стефан (GB)
申请号：
RU2014150850
公开号：
RU2014150850A
申请日:
2013.05.16
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A nanoparticle comprising a biologically active polypeptide, where the nanoparticle comprises poly (oktiltsianoakrilat) .2. A nanoparticle according to claim. 1, which is administered peroralno.3. A nanoparticle according to Claim. 1, wherein the biologically active polypeptide comprises 70 or fewer amino acid ostatkov.4. A nanoparticle according to Claim. 1, wherein the biologically active polypeptide includes metabolic peptid.5. A nanoparticle according to claim. 4, wherein the peptide is a metabolic insulinotropic peptide or inkretin.6. A nanoparticle according to claim. 4, where metabolic peptide is selected from the group consisting of a peptide agonist of GLP-1, PYY, NMU and CCK.7. A nanoparticle according to claim. 4, where metabolic peptide is exendin-4.8. A nanoparticle according to claim. 7, where the nanoparticle has a mean hydrodynamic diameter of 300 nm or menee.9. The population of nanoparticles comprising nanoparticles according to claim 1, wherein at least 90% of the number of nanoparticles has a hydrodynamic diameter in the range 10 nm -. 200 nm, a specific dynamic scattering methods sveta.10. A method of producing nanoparticles according to claim 1, comprising the steps of: a) dissolving oktiltsianoakrilata in an organic solvent to form a monomer solution b) adding a monomer solution of step (a) to the acidic aqueous solution to form an emulsion of organic droplets in the aqueous phase and simultaneously or posledovatelnoc. ) adding an aqueous solution of a biologically active polypeptide to the emulsion from step (b) and providing polymerizable monomer and d) providing the evaporation of the organic phase, thereby obtaining an aqueous suspension of nanoparticles of poly (octyl acrylate) and comprising polipeptid.11. The method of claim. 10 wherein the organic solvent is selected from the group consisting of ethyl acetate, dichloromethane and hloroforma.12. The method of claim. 11 wherein the aqueous solution of step1. Наночастица, включающая би
