Yumei XIONG,Yi ZHANG,Jackie Z. SHENG,Agnes Eva HAMBURGER,Murielle M. VENIANT-ELLISON,Grant SHIMAMOTO,Xiaoshan MIN,Zhulun WANG,Jie TANG,Gunasekaran KANNAN,Kenneth W. WALKER,Bryan LEMON
申请号：
US16416050
公开号：
US20190315822A1
申请日:
2019.05.17
申请国别(地区):
US
年份:
2019
代理人:
摘要：
GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
