治療癌症的HSP90抑制劑和PD-1抑制劑的組合療法

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专利权人:

Synta Pharmaceuticals Corp.

发明人:

PROIA, David A.,RAO, Patricia E.

申请号：

HK18103926.3

公开号：

HK1244436A

申请日:

2018.03.21

申请国别(地区):

HK

年份:

2018

代理人:

摘要：

A pharmaceutical composition comprising a PD-1 inhibitor and a Hsp90 inhibitor, or a tautomer, or a pharmaceutically acceptable salt thereof, wherein the Hsp90 inhibitor is 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(1-methyl-indol-5-yl)-5-hydroxy-[1,2,4] triazole or 5-hydroxy-4-(5-hydroxy-4-(1-methyl-1H-indol-5-yl)-4H-1,2,4-triazol-3-yl)-2-isopropylphenyl dihydrogen phosphate. Also provided is a method for treating cancer in a subject in need thereof, using the pharmaceutical composition described herein.

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