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Anti-CDH3 humanized antibody, drug conjugate thereof, and use thereof
专利权人:
发明人:
Keisuke Ishii,Katsuyuki Mitomo,Katsushi Kouda,Fumiko Nomura,Yoko Kayukawa,Tadashi Matsuura
申请号:
US14768151
公开号:
US09644028B2
申请日:
2014.02.14
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention provides an anti-CDH3 humanized antibody having lower immunogenicity, and an anti-CDH3 humanized antibody drug conjugate having the aforementioned anti-CDH3 humanized antibody. The present invention provides a conjugate of an anti-CDH3 humanized antibody and a drug by conjugating a drug having cytotoxicity to an anti-CDH3 humanized antibody having complementarity determining region sequences derived from the heavy chain variable region of an antibody produced by cells having Accession No. NITE BP-1536, and complementarity determining region sequences derived from the light chain variable region thereof, and which also comprises a heavy chain human subgroup III consensus framework sequence or a human germline sequence selected under optimal alignment as a framework region sequence of the heavy chain variable region, and a light chain human κ subgroup I consensus framework sequence or a human germline sequence selected under optimal alignment as a framework region sequence of the light chain variable region.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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