#$%^&*AU2015243070A120151105.pdf#####H: grs Intrwovn NRPortbl DCC GRS 8649772_I.docx-16/10/2015 NOVEL KINASE MODULATORS ABSTRACT The present invention provides P13K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.