Disclosed are compounds of the formula: wherein R1, R2, R3 and R4 are independently hydrogen, C1-C6 alkyl, halo, a sulfate, a glucuronide, &mdash；OH, a bulky group, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, &mdash；N(CH2)n； a phosphate group, and a phosphinate group； R9 is hydrogen, halogen or alkyl； R11 is selected from the group consisting of H, C1-C6 alkyl, halogen, a sulfate, a glucoronide, &mdash；SO2NH2, &mdash；COOH, &mdash；CN, &mdash；CH2CN&mdash；, &mdash；NHCN&mdash；, &mdash；CHO, &boxH；CHOCH3, &mdash；COO salt, &mdash；OSO2alkyl, &mdash；NH2, and &mdash；NHCO(CH2)n； R12 is selected from the group consisting of H, a C1-C6 alkyl, a sulfate, a glucoronide, a bulky group, aryl, cycloalkyl, heteroaryl and heterocycloalkyl； X is selected from the group consisting of C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, halogen, a glucoronide, &mdash；NH2, &mdash；SO2NH2, &mdash；COOH, &mdash；CN, &mdash；CH2CN, &mdash；NHCN, &mdash；CHO, &mdash；COOsalt, &mdash；OSO2alkyl, &mdash；SH, &mdash；SCH3, &mdash；CH[(CH2)nCH2]COOCH2, &mdash；(CH2)mCOOCH3, &mdash；(CH2)m&mdash；O&mdash；CH3, &mdash；(CH2)m&mdash；O&mdash；(CH2)nCH3, (CH2)m&mdash；S&mdash；CH3, &mdash；(CH2)m&mdash；S&mdash；(CH2)nCH3, &mdash；(CH2)m&mdash；NH&mdash；(CH2)nCH3, &mdash；C2-C8 alkenyl-O&mdash；(CH2)nCH3, &mdash；C2-C8 alkenyl-S&mdash；(CH2)nCH3, &mdash；C2-C8 alkenyl-N&mdash；(CH2)nCH3, &mdash；C2-C8 alkynyl-O&mdash；(CH2)nCH3, &mdash；C2-C8 alkynyl-S&mdash；(CH2)nCH3, &mdash；C2-C8 alkynyl-N&mdash；(CH2)nCH3, &mdash；(CH2)m&mdash；OH, &mdash；(CH2)m&mdash；O&mdash；NH2, &mdash；(CH2)m&mdash；S&mdash；NH2, &mdash；NH(CH2)mCH3, &mdash；NH(CH2)mOCH3, &mdash；NH(CH2)mCHOH&mdash；COOH, &mdash；N(CH3)2, &mdash；(CH2)m(NH)CH2OH, &mdash；NHCOOH, &mdash；(CH2)mNHCOOH, &mdash；NO2, &mdash；SCN, &mdash；SO2alkyl, &mdash；B(OH)2, &mdash；(CH2)m N(CH3)&mdash；SO2&mdash；NH3, &mdash；(CH2)m&mdash；NH&mdash；SO2&mdash；NH2, &mdash；NHC(&boxH；S)CH3, and &mdash；NHNH2； and Y is selected from hydrogen, &boxH；O, &mdash；OCO(R6) and &mdash；OH； wherein m is an integer between 0-20, n is a
