PROBLEM TO BE SOLVED: To provide an enzyme activity inhibitor for GAPDH.SOLUTION: The enzyme activity inhibitor, oxidative modification inhibitor, nuclear translocation inhibitor for GAPDH, and a pharmaceutical composition for cell protection or cytotoxicity treating comprises carbon monoxide and/or heme.COPYRIGHT: (C)2012,JPO&INPIT【課題】GAPDHの酵素活性阻害剤を提供する。【解決手段】一酸化炭素及び/又はヘムを含む、GAPDHの酵素活性阻害剤、酸化修飾阻害剤、核内移行阻害剤、細胞保護用又は細胞障害治療用医薬組成物。【選択図】なし