The endoscope (1) is disposed in the insertion section (2), and a guide line (26) in which the guide wire (300) is inserted in a direction opposite to the insertion direction S of the insertion section (2); A curved conduit (27) that curves to communicate with the base (28) of the treatment instrument insertion port (25) disposed in the operation section (3) and the base (28) are detachable. The opening (35) was shifted from the center of the base (28) to the outer peripheral side in the bending direction of the curved pipe (27).内視鏡(1)は、挿入部(2)内に配設されて、ガイドワイヤ(300)が挿入部(2)の挿入方向Sとは反対方向に挿入される管路(26)と、管路(26)を操作部(3)に配設される処置具挿通口(25)の口金(28)に連通するように湾曲する湾曲管路(27)と、口金(28)に着脱自在な鉗子栓(30)と、を備え、開口(35)を口金(28)の中心から湾曲管路(27)の曲がり方向の外周側にずらして配置した。