Methods and articles of manufacture for treating patients with degenerative bone are provided. The methods are useful to improve bone quality in a localized area of a degenerative bone (e.g., osteopenic or osteoporotic bone), such as by improving BMD to be substantially similar to BMD in an average, healthy individual at the age of peak BMD. The methods can comprise forming a void in a localized area of the degenerative bone and filling the void with a bone regenerative material that causes generation of new, healthy, natural bone material. The articles of manufacture can comprise kits formed of various materials useful in the inventive methods for improving bone quality.提供了用於治療具有變性骨之病人的方法以及製造的物品。該方法有用於改善變性骨(例如,骨量減少或骨質疏鬆的骨頭)局部區域中的骨質,例如藉由將BMD改善成大體上類似於高峰BMD年齡之平均、健康個體中的BMD。該方法可包含在該變性骨的局部區域中形成空隙,以及以骨再生材料填補該空隙,該骨再生材料造成新的、健康的、天然的骨材料產生。該製造的物品可包含由有用於該創造性方法而用於改善骨質之各種材料所形成的套組。