MEVELLEC, Laurence Anne,KENNIS, Ludo Edmond Josephine,MERTENS, Josephus Carolus,VAN DUN, Jacobus Alphonsus Josephus,SOMERS, Maria Victorina Francisca,WOUTERS, Walter Boudewijn Leopold
申请号：
ES05761151
公开号：
ES2563954T3
申请日:
2005.06.28
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I), ** Formula ** an N-oxide form, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, in which n is 0, 1, 2 or 3, and when n is 0, then a direct link is planned； Q is -C (>； = O) -； X is -CH <；and Y is -N <；or -NH-； or X is -N <；and Y is -CH <；or -CH2-； L1 is a direct link or -NH-； L2 is a direct bond or a bivalent radical selected from -C 1-6 alkanediyl-, C2-6 alkanediyl-, carbonyl or -C 1-6 alkanediyl- substituted with a substituent selected from hydroxy or aryl； R1 is hydrogen, nitro, halo or amino； R2 is hydrogen, C1-6 alkyl or aryl-C1-6 alkyl； the central rest can also be bridged (that is, forming a bicyclic moiety) with an ethylene bridge； Z is hydrogen, hydroxy, C1-6 alkyl, C1-6 alkyl-oxy, aryloxy, amino, cyano, aryl-C1-6-amino alkyl or benzothiazolyl (C1-6 alkyl) amino or an annular system selected from ** Formula ** in which R4 and R5 are each independently selected from hydrogen, halo, C1-6 alkyl, C1-6-oxy alkyl or trihalomethyl； aryl is phenyl, or phenyl substituted with one or two substituents each independently selected from halo, C1-6 alkyl or C1-6 alkyl； with the proviso that when Q is -C (>； = O) - and X is -N <；and Y is -CH <；or -CH2- and L1 is a direct link and L2 is a direct link, or the bivalent radical - C 1-6 alkanediyl or C 1-6 alkanediyl substituted with hydroxy, and R 1 is hydrogen, and R 2 is hydrogen or C 1-6 alkyl, then Z is other than hydrogen, hydroxy or C 1-6 alkyl； and with the proviso that the following compounds are excluded ** Formula **Un compuesto de fórmula (I),**Fórmula** una forma de N-óxido, una sal de adición farmacéuticamente aceptable o una forma estereoquímicamente isomérica del mismo, en la que n es 0, 1, 2 o 3, y cuando n es 0, entonces está previsto un enlace directo； Q es -C(>；=O)-； X es -CH<； e Y es -N<； o -NH-； o X es -N<； e Y es -CH<； o -CH2-； L1 es un enlace directo o -NH-； L2 es un enlace directo o un radical bivalente seleccio
