Controlled release methylphenidate compostions comprising at least two groups of particles, each with a methylphenidate core coated with a controlled release polymer coating, each group distinguished by the coating thickness
Disclosed is a controlled release pharmaceutical composition comprising a plurality of particles for release control. The plurality of particles comprise a core material containing methylphenidate and a polymer coating layer for release control formed on the core material, wherein the plurality of particles for release control are identical in terms of the composition of the polymer in the polymer coating layer, but are divided into two or more groups based on the average thickness of the polymer coating layer for release control. The polymer of the polymer coating layer is a water-insoluble polymer, or a combination of the water-insoluble polymer and one or more selected from a group consisting of a water insoluble polymer, an enteric polymer and a gastric polymer. The particle groups for release control comprise a first particle group having an average coating layer thickness of 1 to 120 micron, and a second particle group having an average coating layer thickness of 10 to 250 micron.
