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BET-PROTEIN-INHIBITING DIHYDROPYRIDOPYRAZINONES
专利权人:
发明人:
Norbert SCHMEES,Benjamin BADER,Bernard HAENDLER,Detlef STÖCKIGT,Pascale LEJEUNE,Amaury Ernesto FERNANDEZ-MONTALVAN,Timo STELLFELD,Daniel GALLENKAMP
申请号:
US14654572
公开号:
US20160193206A1
申请日:
2013.12.17
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention relates to BET protein-inhibitory, especially BRD4-inhibitory, dihydropyridopyrazinones of the general formula (I)in which A, X, R1, R2, R3, R4, R4, R6, R7 and n have the meanings given in the description, to intermediates for preparation of the compounds according to the invention, to pharmaceutical compositions comprising the compounds according to the invention, and to the prophylactic and therapeutic use thereof in the case of hyperproliferative disorders, especially in the case of neoplastic disorders.This invention further relates to the use of BET protein inhibitors in viral infections, in neurodegenerative disorders, in inflammation diseases, in atherosclerotic disorders and in male fertility control.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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