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PEPTIDE ANTIBIOTIC COMPLEXES AND METHODS OF USE THEREOF
专利权人:
GENENTECH; INC.
发明人:
PETER ANDREW SMITH,JEREMY MARK MURRAY,MICHAEL FRIEDRICH THOMAS KOEHLER,CHRISTOPHER E. HEISE
申请号:
US16829963
公开号:
US20200262869A1
申请日:
2020.03.25
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided herein are compounds that form covalent bonds with peptidases, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SPase), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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