To provide anti-podoplanin antibodies with high binding activity and high effector activity.SOLUTION: Disclosed herein is a human chimeric or humanized anti-podoplanin monoclonal antibody having a rodent-derived CDR in the variable region and a human-derived constant region, where the light chain constant region is a human λ chain constant region. Also disclosed is an antibody-drug complex prepared by linking an antibody and a drug. The drug may be an anti-cancer agent, a kidney disease treating agent, or a radio isotope.SELECTED DRAWING: None【課題】結合活性及びエフェクター活性の高い抗ポドプラニン抗体の提供。【解決手段】可変領域にげっ歯類由来のＣＤＲを有し、定常領域がヒト由来であるヒトキメラ又はヒト化抗ポドプラニンモノクローナル抗体であって、軽鎖定常領域にヒトλ鎖の定常領域を有するヒトキメラ又はヒト化抗ポドプラニンモノクローナル抗体。抗体と薬物とを結合させてなる抗体薬物複合体。薬物が、抗がん剤、腎臓病治療剤、ラジオアイソトープである抗体薬物複合体【選択図】なし
