Bruce A. Sullenger,Shahid Nimjee,Sabah Oney,Nanette Que-Gewirth
申请号：
US14444431
公开号：
US09873727B2
申请日:
2014.07.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of a receptor, such as glycoprotein IIb/IIIa (gpIIb/IIIa), and to aptamers suitable for use in such a method. The invention also relates to antidotes to antiplatelet agents and to methods of using such antidotes to reverse aptamer-induced platelet inhibition. The invention further relates to von Willebrand Factor (VWF) inhibitors, and antidotes therefore, and to methods of using same.
