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Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
专利权人:
SIGNAL PHARMACEUTICALS LLC
发明人:
Sapienza John,Parnes Jason,Papa Patrick,Whitefield Brandon Wade,Norris Stephen,Plantevin-Krenitsky Veronique,Cashion Daniel,Delgado Maria Mercedes,Huang Dehua,Mortensen Deborah,Correa Matthew,Hansen J
申请号:
NZ71725714
公开号:
NZ717257A
申请日:
2014.09.02
申请国别(地区):
NZ
年份:
2017
代理人:
摘要:
Disclosed herein are alkylheteroaryl-diaminopyrimidyl compounds of the general formula (I), wherein the substituents are as defined in the specification. The disclosed compounds selectively inhibit PKC-theta without affecting the other members of the PKC family such as PKC-delta and/or PKC-eta. Also disclosed is the use of compounds of formula (I) for the treatment of PKC-theta mediated disorders such as graft-versus-host disease, organ transplant rejection, psoriasis, Duchenne muscular dystrophy, rheumatoid arthritis, diabetes, insulin resistance, myasthenia gravis,multiple sclerosis, colitis, psoriatic arthritis, ankylosing spondylitis, atopic dermatitis, Sjogren syndrome, asthma, or lupus. Examples of a compound of formula (I) are: 2-(((4-(2,2-Difluoropropoxy)pyrimidin-5-yl)methyl)amino)-4-(((1R,4S)-4-hydroxy-3,3-dimethylcyclohexyl)amino)pyrimidine-5-carbonitrile 4-(((1S,4R)-4-Hydroxy-3,3-dimethylcyclohexyl)amino)-2-((2-(5-methyl-1Htetrazol-1-yl)benzyl)amino)pyrimidine-5-carbonitrile (1S,3R)-3-(2-((4-Isopropylpyrimidin-5-yl)methylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)-2,2-dimethylcyclobutanol 3-(((5-Cyano-4-(((1s,4s)-4-hydroxy-4-methylcyclohexyl)amino)pyrimidin-2-yl)amino)methyl)-4-(trifluoromethyl)pyridine 1-oxide
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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