DAVID MALCOLM CROWE,HANNAH JOY EDWARDS,HAYDN BEATON,NICHOLAS JAMES GRIFFITHS-HAYNES
申请号：
BR112018073521
公开号：
BR112018073521A2
申请日:
2017.06.01
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The present invention relates to novel n - [(3-fluoro-4-methoxypyridin-2-yl) methyl] -3- (methoxymethyl) -1 - ({4 - [(2-oxopyridin-1-yl) polymorphs ) methyl] phenyl] phenyl} methyl) pyrazol-4-carboxamide and their salts, pharmaceutical compositions containing them and their use as kallikrein inhibitors in therapy.a presente invenção refere-se aos novos polimorfos de n-[(3-flúor-4-metoxipiridin-2-il)metil]-3-(metoximetil)-1-({4-[(2-oxopiridin-1-il)metil]fenil]fenil}metil)pirazol-4-carboxamida e os sais dos mesmos, as composições farmacêuticas contendo-os e ao seu uso como inibidores de calicreína em terapia.
